HitPredict

Interactor 1: ATF2 (P16951)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (MXBP protein) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Interactor 2: MK08 (Q91Y86)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: Mapk8

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	15304344
Identification Methods	experimental interaction detection
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0007254 - JNK cascade GO:0043525 - positive regulation of neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Mm			1 384
+	Hs
		547742 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK08_HUMAN (1-378): 4.15e-147: 424: 100.00
+	Hs
		547757 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK10_HUMAN (1-382): 9.87e-146: 422: 91.62
+	Hs
		547743 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK09_HUMAN (1-380): 1.24e-143: 416: 83.42
+	Mm
		562984 ATF2_MOUSE (1-487): 2.97e-130: 388: 100.00		MK09_MOUSE (1-380): 1.59e-142: 413: 84.74
+	Hs
		547805 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK11_HUMAN (4-363): 3.89e-137: 397: 47.11
+	Mm
		562985 ATF2_MOUSE (1-487): 2.97e-130: 388: 100.00		MK11_MOUSE (4-365): 9.73e-138: 398: 46.85
+	Hs
		173828 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK13_HUMAN (6-373): 8.26e-127: 371: 45.41
+	Hs
		547811 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK14_HUMAN (4-366): 3.96e-127: 371: 45.90
+	Mm
		562973 ATF2_MOUSE (1-487): 2.97e-130: 388: 100.00		MK14_MOUSE (4-366): 1.66e-127: 372: 45.90
+	Rn
		102456 ATF2_RAT (1-487): 3.94e-130: 387: 98.77		G3V617_RAT (4-366): 1.17e-127: 372: 45.90
+	Hs
		568251 ATF7_HUMAN (1-482): 7.98e-109: 333: 54.69		MK08_HUMAN (1-378): 4.15e-147: 424: 100.00
+	Hs
		547713 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK01_HUMAN (20-359): 8.67e-84: 261: 42.98
+	Hs
		547709 ATF2_HUMAN (1-477): 7.42e-134: 398: 99.58		MK03_HUMAN (20-359): 1.48e-82: 258: 41.26
+	Mm
		562975 ATF2_MOUSE (1-487): 2.97e-130: 388: 100.00		MK01_MOUSE (20-359): 9.09e-84: 261: 42.98
+	Mm
		562980 ATF2_MOUSE (1-487): 2.97e-130: 388: 100.00		MK03_MOUSE (20-370): 1.78e-83: 261: 40.56
+	Hs
		566734 JUNB_HUMAN (69-405): 4.99e-44: 160: 15.08		MK08_HUMAN (1-378): 4.15e-147: 424: 100.00
+	Hs
		566735 JUNB_HUMAN (69-405): 4.99e-44: 160: 15.08		MK09_HUMAN (1-380): 1.24e-143: 416: 83.42
+	Rn
		567363 JUN_RAT (113-413): 5.98e-41: 151: 18.15		MK08_RAT (1-378): 1.92e-146: 422: 99.47
+	Rn
		567365 JUN_RAT (113-413): 5.98e-41: 151: 18.15		MK10_RAT (1-382): 1.1e-145: 422: 91.62
+	Rn
		567364 JUN_RAT (113-413): 5.98e-41: 151: 18.15		MK09_RAT (1-380): 1.62e-141: 410: 83.16