HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: PTBP1 (P26599)
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Gene: PTBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	14966131, 29924966, 31324722, 39009827
Identification Methods	nucleic acid uv cross-linking assay, pull down, cross-linking study, phage display
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 557
+	Hs
		550101 CFTR_HUMAN (1-1480): 0: 1106: 100.00		PABP1_HUMAN (3-375): 2.22e-45: 171: 13.58
+	Hs
		564358 CFTR_HUMAN (1-1480): 0: 1106: 100.00		PABP3_HUMAN (3-375): 6.42e-45: 170: 13.42
+	Hs
		563717 CFTR_HUMAN (1-1480): 0: 1106: 100.00		PABP4_HUMAN (3-378): 2.7e-44: 168: 10.62
+	Hs
		563856 CFTR_HUMAN (1-1480): 0: 1106: 100.00		PAP1L_HUMAN (7-277): 6.43e-30: 126: 12.86
+	Hs
		477904 CFTR_HUMAN (1-1480): 0: 1106: 100.00		SNRPA_HUMAN (361-471): 6.98e-19: 89.1: 16.38
+	Hs
		563120 CFTR_HUMAN (1-1480): 0: 1106: 100.00		HNRPL_HUMAN (15-252): 6.55e-10: 63.7: 13.31