HitPredict

Interactor 1: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Interactor 2: RFFL (Q8WZ73)
E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)
Gene: RFFL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 643 Hs			1 363
+	Hs
		871704 HSP72_HUMAN (3-643): 0: 925: 77.45		RFFL_HUMAN (1-363): 9.46e-153: 436: 100.00
+	Hs
		504525 HSP7C_HUMAN (4-615): 0: 940: 79.25		RNF34_HUMAN (1-363): 1.87e-113: 336: 43.05
+	Hs
		871714 HSP72_HUMAN (3-643): 0: 925: 77.45		RNF34_HUMAN (1-363): 1.87e-113: 336: 43.05
+	Hs
		282501 HSP7C_HUMAN (4-615): 0: 940: 79.25		RNF8_HUMAN (142-357): 1.21e-37: 142: 16.81
+	Hs
		504031 HSP7C_HUMAN (4-615): 0: 940: 79.25		BIRC3_HUMAN (231-363): 4.4e-34: 134: 22.30
+	Dm
		669792 HSP7A_DROME (4-643): 0: 952: 75.78		DIAP2_DROME (151-363): 3.31e-23: 102: 14.16
+	Dm
		505058 HSP7D_DROME (4-614): 0: 923: 79.38		DIAP2_DROME (151-363): 3.31e-23: 102: 14.16
+	Dr
		1157472 Q6NYR4_DANRE (4-616): 0: 931: 78.47		MIB1_DANRE (303-361): 1.89e-10: 64.5: 33.90