HitPredict

Interactor 1: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21988832
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 643 Hs			1 258
+	Hs
		442775 HSP76_HUMAN (1-643): 0: 970: 100.00		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		181791 HSP76_HUMAN (1-643): 0: 970: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		411586 HSP76_HUMAN (1-643): 0: 970: 100.00		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		433227 HSP7C_HUMAN (4-615): 0: 940: 79.25		YES_HUMAN (50-213): 3.31e-43: 155: 16.28
+	Hs
		503340 HSP7C_HUMAN (4-615): 0: 940: 79.25		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		411965 HSP7C_HUMAN (4-615): 0: 940: 79.25		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		442767 HSP7C_HUMAN (4-615): 0: 940: 79.25		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		147499 HSP72_HUMAN (3-643): 0: 925: 77.45		SOCS6_HUMAN (46-256): 4.63e-45: 160: 25.69
+	Hs
		181781 HSP7C_HUMAN (4-615): 0: 940: 79.25		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		411570 HSP7C_HUMAN (4-615): 0: 940: 79.25		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		129192 HSP76_HUMAN (1-643): 0: 970: 100.00		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		129217 HS71L_HUMAN (1-643): 0: 960: 79.32		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		503950 HSP7C_HUMAN (4-615): 0: 940: 79.25		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		503489 HSP7C_HUMAN (4-615): 0: 940: 79.25		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129181 HSP7C_HUMAN (4-615): 0: 940: 79.25		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42