HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 753
+	Hs
		647958 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		647872 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		647868 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		647856 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		647858 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		545213 RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		647867 RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		1183120 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		564584 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		951102 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		925384 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		894157 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		900617 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		545461 RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		894319 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		MARK4_HUMAN (1-753): 0: 612: 60.24
+	Hs
		925283 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		MELK_HUMAN (47-753): 2.32e-173: 514: 27.65
+	Hs
		894016 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		MELK_HUMAN (47-753): 2.32e-173: 514: 27.65
+	Hs
		545381 RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03		MELK_HUMAN (47-753): 2.32e-173: 514: 27.65
+	Hs
		894405 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		SIK2_HUMAN (53-364): 2.39e-107: 350: 54.89
+	Hs
		1219185 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		BRSK2_HUMAN (47-500): 2.68e-79: 271: 36.11