HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 987
+	Hs
		872575 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		EPHB4_HUMAN (1-987): 0: 1122: 100.00
+	Hs
		1072595 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Hs
		872525 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		EPHB4_HUMAN (1-987): 0: 1122: 100.00
+	Hs
		872522 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		EPHB4_HUMAN (1-987): 0: 1122: 100.00
+	Hs
		872516 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		EPHB4_HUMAN (1-987): 0: 1122: 100.00
+	Hs
		564541 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Hs
		951011 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Hs
		872424 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		EPHA5_HUMAN (1-978): 0: 1099: 47.77
+	Hs
		925297 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Hs
		872423 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		EPHA5_HUMAN (1-978): 0: 1099: 47.77
+	Hs
		872419 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		EPHA5_HUMAN (1-978): 0: 1099: 47.77
+	Hs
		665332 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		564420 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		665208 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		665201 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		665192 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		665194 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		564424 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		UFO_HUMAN (265-915): 2.92e-141: 446: 24.10
+	Rn
		544912 CDC42_RAT (9-193): 1.09e-78: 235: 67.57		INSR_RAT (380-879): 6.3e-136: 444: 30.43
+	Hs
		925220 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		FAK1_HUMAN (595-878): 1.01e-61: 230: 41.55