HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 776
+	Hs
		1066050 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Hs
		925289 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Gg
		1141019 Q6LC82_CHICK (10-195): 4.15e-80: 238: 63.98		ARHG6_CHICK (1-775): 0: 589: 73.55
+	Hs
		1049733 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		564524 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		925271 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		951449 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03
+	Hs
		548678 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		VAV_HUMAN (1-746): 1.59e-120: 384: 16.20
+	Hs
		855782 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14
+	Hs
		50617 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		50555 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		951099 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		PREX2_HUMAN (220-543): 5.59e-83: 291: 21.39
+	Hs
		564737 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53
+	Hs
		925382 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		PREX2_HUMAN (220-543): 5.59e-83: 291: 21.39
+	Hs
		50582 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		50580 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		925405 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		ARHGP_HUMAN (218-656): 3.19e-79: 267: 18.87
+	Hs
		224711 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		KALRN_HUMAN (203-772): 1.73e-74: 266: 17.83
+	Hs
		279855 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		TRIO_HUMAN (230-567): 1.42e-72: 261: 20.46
+	Hs
		279854 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		TRIO_HUMAN (230-567): 1.42e-72: 261: 20.46