HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31871319, 15194684
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 1732
+	Hs
		1137905 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		951069 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		1331011 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		564758 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		951494 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		564571 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		MRCKG_HUMAN (4-1712): 0: 1145: 39.90
+	Hs
		925229 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		DMPK_HUMAN (1-539): 8.55e-141: 451: 48.17
+	Hs
		148653 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Mm
		823530 RAC1_MOUSE (10-195): 4.15e-80: 238: 63.98		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Hs
		564425 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		AKT2_HUMAN (13-391): 2.91e-129: 414: 30.65
+	Hs
		681775 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Mm
		925783 RAC1_MOUSE (10-195): 4.15e-80: 238: 63.98		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Hs
		254512 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		1035206 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		254445 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254472 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		564514 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		254468 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		950974 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		925253 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28