HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	32296183, 11162552, 10934474, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 372
+	Hs
		1316964 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		1316959 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		951299 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		925587 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		925586 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Ce
		983039 CDC42_CAEEL (10-193): 3.51e-91: 266: 67.94		PAR6_CAEEL (4-273): 2.54e-89: 273: 52.19
+	Hs
		564698 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		925642 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		159267 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		1132891 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		159153 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		159192 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		159189 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		564561 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		951060 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		925341 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		1050061 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		564526 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		950989 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		925273 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83