HitPredict

Interactor 1: RU17 (P17133)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: snRNP-U1-70K

Interactor 2: RUXF (Q24297)
Small nuclear ribonucleoprotein F (snRNP-F) (Membrane-associated protein Deb-B) (Sm protein F) (Sm-F) (SmF)
Gene: SmF

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LSM~U1snRNP70_N
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005681 - spliceosomal complex GO:0005685 - U1 snRNP GO:0071011 - precatalytic spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 448 Dm			1 88
+	Hs
		442631 RU17_HUMAN (1-223): 3.25e-49: 175: 66.96		LSM4_HUMAN (9-82): 2.84e-33: 113: 29.33
+	Hs
		442012 RU17_HUMAN (1-223): 3.25e-49: 175: 66.96		RUXF_HUMAN (5-77): 4.96e-32: 108: 82.19
+	Hs
		911852 U1SBP_HUMAN (82-298): 1.72e-50: 173: 35.48		RUXF_HUMAN (5-77): 4.96e-32: 108: 82.19
+	Dm
		218355 RU17_DROME (1-448): 3.81e-56: 193: 100.00		SMD3_DROME (9-78): 3.61e-22: 85.3: 22.86
+	Hs
		442613 RU17_HUMAN (1-223): 3.25e-49: 175: 66.96		LSM2_HUMAN (11-88): 1.3e-24: 90: 28.40
+	Hs
		442016 RU17_HUMAN (1-223): 3.25e-49: 175: 66.96		SMD3_HUMAN (9-78): 8.25e-24: 88.8: 22.86
+	Hs
		912648 U1SBP_HUMAN (82-298): 1.72e-50: 173: 35.48		SMD3_HUMAN (9-78): 8.25e-24: 88.8: 22.86
+	Sc
		873653 RU17_YEAST (3-264): 1.71e-41: 151: 27.78		RUXF_YEAST (1-79): 2.7e-28: 98.8: 53.75
+	Sc
		795407 RU17_YEAST (3-264): 1.71e-41: 151: 27.78		SMD3_YEAST (9-78): 6.91e-24: 88.4: 24.29
+	Sp
		143344 RU17_SCHPO (1-267): 1.31e-35: 134: 35.58		RUXF_SCHPO (3-76): 5.56e-30: 103: 67.57
+	Sc
		376892 PABP_YEAST (9-341): 2.75e-33: 133: 10.15		RUXF_YEAST (1-79): 2.7e-28: 98.8: 53.75
+	Sp
		143359 RU17_SCHPO (1-267): 1.31e-35: 134: 35.58		SMD3_SCHPO (10-78): 3.76e-25: 91.5: 21.74
+	Sc
		376759 PABP_YEAST (9-341): 2.75e-33: 133: 10.15		LSM2_YEAST (11-88): 6.75e-22: 83: 28.40
+	Sc
		376804 PABP_YEAST (9-341): 2.75e-33: 133: 10.15		LSM4_YEAST (9-83): 4.3e-20: 81.1: 26.74