HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: PCL7 (P40186)
PHO85 cyclin-7 (PHO85-associated protein 1)
Gene: PCL7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	9032248, 11069666, 11283351, 10688190, 11805837, 16611745, 18719252, 37968396, 20489023, 16429126
Identification Methods	two hybrid, two hybrid pooling approach, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005979 - regulation of glycogen biosynthetic process GO:0031647 - regulation of protein stability
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Sc			1 285
+	Sc
		339669 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		PCL7_YEAST (1-285): 4.69e-117: 339: 100.00
+	Sc
		565612 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		PCL6_YEAST (50-284): 8.48e-65: 210: 43.43
+	Sc
		565812 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		PCL8_YEAST (30-273): 1.75e-61: 203: 22.18
+	Hs
		960388 CDK16_HUMAN (7-297): 3.3e-125: 368: 54.64		CCYL1_HUMAN (30-284): 2.06e-69: 220: 18.28
+	At
		621726 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU21_ARATH (89-280): 1.18e-61: 196: 27.60
+	At
		621696 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU43_ARATH (84-280): 1.6e-61: 195: 28.43
+	Hs
		960390 CDK16_HUMAN (7-297): 3.3e-125: 368: 54.64		CCNY_HUMAN (36-283): 5.57e-67: 213: 17.11
+	At
		621719 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU22_ARATH (89-280): 1.33e-59: 191: 28.65
+	Sc
		339662 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		PCL6_YEAST (50-284): 8.48e-65: 210: 43.43
+	At
		621714 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU42_ARATH (101-280): 1.49e-58: 188: 30.56
+	At
		285423 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU41_ARATH (107-280): 1.64e-58: 187: 36.21
+	Sc
		565703 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		PCL10_YEAST (57-281): 1.81e-49: 170: 22.17
+	At
		621706 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	At
		621675 CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17		CCU31_ARATH (144-280): 1.95e-51: 170: 31.39
+	At
		1227956 CKB21_ARATH (1-305): 1.26e-126: 365: 41.53		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	At
		1228089 CKB22_ARATH (1-305): 2.33e-126: 364: 42.17		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	Sp
		195004 PEF1_SCHPO (6-297): 1.9e-125: 361: 58.22		PSL1_SCHPO (86-282): 6.93e-55: 179: 42.42
+	Mm
		88307 CDK16_MOUSE (7-297): 5.03e-105: 317: 55.33		CCYL1_MOUSE (30-284): 5.63e-70: 222: 18.28
+	Mm
		980962 CDK16_MOUSE (7-297): 5.03e-105: 317: 55.33		CCNY_MOUSE (36-283): 1.64e-66: 212: 17.11
+	Sc
		565447 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		PHO80_YEAST (92-264): 8.38e-35: 128: 27.27