HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: RIM15 (P43565)
Serine/threonine-protein kinase RIM15 (EC 2.7.11.1)
Gene: RIM15

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	11805837, 16308562
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016310 - phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 305 Sc			1 1770
+	Sc
		339700 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		RIM15_YEAST (1-1770): 0: 1631: 100.00
+	Hs
		682166 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		AKT2_HUMAN (1051-1317): 9.2e-73: 254: 22.55
+	Hs
		623866 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		KPCL_HUMAN (1050-1321): 3.63e-67: 243: 19.86
+	Hs
		414773 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		AKT1_HUMAN (1051-1317): 4.28e-72: 252: 22.83
+	Sc
		412937 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		KAPB_YEAST (1035-1302): 2.94e-65: 228: 24.54
+	Hs
		960326 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		DCLK3_HUMAN (1081-1275): 6.94e-48: 185: 23.12
+	Hs
		200086 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		DAPK3_HUMAN (1098-1272): 1.53e-32: 135: 24.86
+	Hs
		568628 CDK17_HUMAN (7-297): 1.22e-100: 306: 51.33		KAPCA_HUMAN (1024-1293): 6.51e-68: 235: 25.55
+	Hs
		568639 CDK18_HUMAN (7-297): 6.83e-98: 298: 54.98		KAPCA_HUMAN (1024-1293): 6.51e-68: 235: 25.55
+	Hs
		609663 CDK17_HUMAN (7-297): 1.22e-100: 306: 51.33		KAPCG_HUMAN (1026-1293): 8.54e-63: 220: 24.27
+	Hs
		325633 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		LATS1_HUMAN (1149-1302): 3.8e-20: 100: 42.58
+	Hs
		960349 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		MAST1_HUMAN (1144-1299): 4.62e-24: 113: 38.46
+	Hs
		230862 CDK16_HUMAN (7-297): 3.3e-125: 368: 54.64		MAST3_HUMAN (1144-1299): 1.26e-26: 121: 39.87
+	Hs
		325594 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		LATS1_HUMAN (1149-1302): 3.8e-20: 100: 42.58
+	Hs
		841205 CDK7_HUMAN (2-304): 5.47e-126: 365: 38.76		STK38_HUMAN (1149-1283): 4.47e-24: 109: 41.48
+	Sc
		339777 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		CBK1_YEAST (1149-1282): 5.78e-21: 102: 40.15
+	Sp
		251505 PEF1_SCHPO (6-297): 1.9e-125: 361: 58.22		CEK1_SCHPO (941-1071): 1.08e-17: 92.3: 4.58
+	Hs
		989707 CDK18_HUMAN (7-297): 6.83e-98: 298: 54.98		GWL_HUMAN (1146-1285): 3.99e-23: 109: 42.14