HitPredict

Interactor 1: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Interactor 2: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	9121453, 7559568, 8605876, 33811647, 15356134, 12220192, 9677371
Identification Methods	pull down, affinity chromatography technology, surface plasmon resonance, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0060337 - type I interferon-mediated signaling pathway
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 557 Hs			1 851
+	Hs
		566011 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		566010 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Mm
		708082 INAR1_MOUSE (18-548): 3.31e-113: 350: 48.97		STAT1_MOUSE (1-730): 0: 878: 42.51
+	Hs
		566012 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT6_HUMAN (1-850): 0: 742: 24.19
+	Hs
		819579 INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57		STAT2_HUMAN (1-851): 0: 1027: 100.00
+	Hs
		776851 I20RA_HUMAN (18-268): 6.6e-50: 182: 20.08		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Mm
		786535 I10R1_MOUSE (5-242): 2.46e-44: 167: 17.97		STAT3_MOUSE (1-747): 0: 846: 37.47
+	Hs
		546441 INGR1_HUMAN (225-542): 2.4e-30: 126: 16.19		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Mm
		546502 INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09		Q99K94_MOUSE (1-701): 0: 867: 43.67
+	Mm
		546497 INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09		STAT3_MOUSE (1-747): 0: 846: 37.47
+	Hs
		770183 IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Mm
		786560 INLR1_MOUSE (209-427): 8.11e-26: 113: 17.54		STAT3_MOUSE (1-747): 0: 846: 37.47
+	Hs
		770182 IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		786269 INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		776745 I22R1_HUMAN (233-490): 2.5e-11: 68.4: 14.87		STAT3_HUMAN (1-747): 0: 846: 37.47