HitPredict

Interactor 1: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 672 Hs			1 779
+	Hs
		408682 KPCB_HUMAN (1-664): 0: 749: 78.89		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566377 KPCA_HUMAN (1-672): 0: 794: 100.00		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		682023 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (242-660): 9.73e-156: 459: 39.13		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408612 KPCB_HUMAN (1-664): 0: 749: 78.89		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Mm
		930572 KPCG_MOUSE (16-670): 0: 698: 69.88		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		397159 KPCG_HUMAN (1-670): 0: 706: 68.94		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		969077 KPCE_HUMAN (8-664): 0: 635: 44.61		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		984534 KPCD_HUMAN (9-167): 3.67e-57: 207: 39.65		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		981062 KPCT_HUMAN (18-155): 9.83e-54: 198: 45.52		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		623884 KPCL_HUMAN (31-215): 2e-49: 185: 35.57		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		681831 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (283-660): 1.85e-154: 456: 40.46		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		296529 KPCD3_HUMAN (89-220): 3.42e-21: 100: 24.24		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		784090 KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		984488 KPCD_HUMAN (9-167): 3.67e-57: 207: 39.65		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		784000 KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Dm
		54650 APKC_DROME (22-86): 6.73e-13: 73.9: 44.62		SIF2_DROME (7-634): 3.14e-45: 178: 12.50
+	Hs
		299245 KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69
+	Hs
		299257 KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69