HitPredict

Interactor 1: JUNB (P17275)
Transcription factor JunB (Transcription factor AP-1 subunit JunB)
Gene: JUNB

Interactor 2: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 508
+	Hs
		401872 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		566716 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		547685 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		ATF2_HUMAN (9-503): 1.72e-64: 219: 33.87
+	Hs
		401377 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		401356 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		ATF2_HUMAN (9-503): 1.72e-64: 219: 33.87
+	Hs
		566715 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		JUND_HUMAN (173-450): 4.53e-29: 119: 14.95
+	Hs
		401374 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		566714 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		JUNB_HUMAN (191-447): 3.94e-24: 105: 15.14
+	Hs
		566720 JUNB_HUMAN (1-347): 1.03e-83: 259: 100.00		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Hs
		402260 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		KMT2C_HUMAN (81-383): 3.2e-30: 127: 10.90
+	Mm
		404100 JUN_MOUSE (1-347): 8.87e-57: 189: 44.32		JUN_MOUSE (180-452): 1.89e-29: 120: 17.90
+	Hs
		401376 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		JUND_HUMAN (173-450): 4.53e-29: 119: 14.95
+	Hs
		401257 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Mm
		404138 JUN_MOUSE (1-347): 8.87e-57: 189: 44.32		ATF4_MOUSE (215-437): 6.15e-25: 107: 15.25
+	Hs
		401393 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Nv
		64901 A7RIQ6_NEMVE (5-340): 1.36e-47: 165: 30.96		A7S1A3_NEMVE (225-449): 1.58e-30: 120: 34.22
+	Sp
		945128 ATF21_SCHPO (9-337): 1.37e-51: 176: 15.18		ATF31_SCHPO (309-458): 3.01e-25: 105: 16.46
+	Nv
		64903 A7RIQ6_NEMVE (5-340): 1.36e-47: 165: 30.96		A7S4U5_NEMVE (314-472): 4.65e-25: 104: 23.60
+	Nv
		64904 A7RIQ6_NEMVE (5-340): 1.36e-47: 165: 30.96		A7SB15_NEMVE (370-439): 2.24e-16: 75.5: 35.71