HitPredict

Interactor 1: AP2A2 (P17427)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: EPS15 (P42567)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	10430869, 12057195
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030122 - AP-2 adaptor complex GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 938 Mm			1 897
+	Hs
		302112 AP2A2_HUMAN (1-938): 0: 870: 96.27		EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65
+	Hs
		321504 AP2A1_HUMAN (1-938): 0: 834: 78.04		EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65
+	Rn
		1126749 Q66HM2_RAT (1-938): 0: 888: 99.57		Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33
+	Rn
		88764 D3ZUY8_RAT (1-938): 0: 837: 80.92		Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33
+	Hs
		787903 AP1B1_HUMAN (36-935): 0: 630: 17.32		EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65
+	Mm
		788007 AP2B1_MOUSE (36-933): 0: 624: 16.27		EPS15_MOUSE (1-897): 1.37e-149: 465: 100.00
+	Hs
		302157 AP2A2_HUMAN (1-938): 0: 870: 96.27		ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27
+	Hs
		321552 AP2A1_HUMAN (1-938): 0: 834: 78.04		ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27
+	Hs
		302193 AP2A2_HUMAN (1-938): 0: 870: 96.27		REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21
+	Rn
		88768 D3ZUY8_RAT (1-938): 0: 837: 80.92		ITSN1_RAT (124-817): 1.9e-33: 141: 15.09
+	Hs
		302221 AP2A2_HUMAN (1-938): 0: 870: 96.27		EP15R_HUMAN (417-861): 2.78e-17: 88.9: 12.92
+	Hs
		321615 AP2A1_HUMAN (1-938): 0: 834: 78.04		REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21
+	Hs
		321661 AP2A1_HUMAN (1-938): 0: 834: 78.04		EP15R_HUMAN (417-861): 2.78e-17: 88.9: 12.92
+	Hs
		321640 AP2A1_HUMAN (1-938): 0: 834: 78.04		EHD1_HUMAN (17-102): 2.45e-15: 81.9: 33.72
+	Ce
		1094946 Q22601_CAEEL (3-938): 0: 785: 64.44		Q9U2T9_CAEEL (2-439): 1.16e-23: 109: 12.98
+	Dm
		91156 AP2A_DROME (3-938): 0: 822: 69.57		E3CTP7_DROME (474-790): 1.88e-10: 67: 11.49
+	Hs
		1014017 AP1B1_HUMAN (36-935): 0: 630: 17.32		ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27
+	Hs
		1014096 AP1B1_HUMAN (36-935): 0: 630: 17.32		ITSN2_HUMAN (6-552): 2.33e-26: 118: 11.31
+	Hs
		1014062 AP1B1_HUMAN (36-935): 0: 630: 17.32		REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21
+	Hs
		1014098 AP1B1_HUMAN (36-935): 0: 630: 17.32		EP15R_HUMAN (417-861): 2.78e-17: 88.9: 12.92