HitPredict

Interactor 1: HXB9 (P17482)
Homeobox protein Hox-B9 (Homeobox protein Hox-2.5) (Homeobox protein Hox-2E)
Gene: HOXB9

Interactor 2: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 250 Hs			1 330
+	Hs
		211793 HXB9_HUMAN (1-250): 5.95e-59: 188: 100.00		TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94
+	Hs
		679014 HXC9_HUMAN (1-234): 1.05e-33: 124: 44.31		HXD1_HUMAN (46-293): 5.33e-40: 145: 27.20
+	Dm
		447327 SCR_DROME (127-250): 1.05e-37: 138: 42.42		HMPB_DROME (25-330): 2.02e-30: 123: 19.30
+	Hs
		568043 HXB6_HUMAN (68-245): 3.12e-37: 132: 30.85		ALX4_HUMAN (29-328): 1.44e-30: 121: 18.18
+	Mm
		192283 HXA10_MOUSE (16-246): 5.66e-34: 128: 34.76		ALX4_MOUSE (29-328): 9.59e-32: 124: 17.93
+	Hs
		211799 HXC9_HUMAN (1-234): 1.05e-33: 124: 44.31		TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94
+	Dm
		367190 ANTP_DROME (47-249): 7.38e-30: 116: 25.62		UBX_DROME (65-265): 4.1e-33: 128: 23.83
+	Ce
		712513 LIN39_CAEEL (60-249): 2.11e-33: 123: 29.08		Q19937_CAEEL (100-273): 1.74e-32: 121: 25.14
+	Hs
		446885 HXB5_HUMAN (7-249): 2.13e-30: 115: 24.42		HXC4_HUMAN (109-293): 2.37e-34: 128: 25.39
+	Dm
		950014 UBX_DROME (39-246): 5.08e-29: 114: 25.24		Q7KS72_DROME (117-320): 9.15e-34: 128: 49.52
+	Hs
		174008 SHOX_HUMAN (164-249): 8.53e-30: 114: 31.40		SHOX_HUMAN (185-299): 6.57e-34: 127: 25.22
+	Mm
		192275 ALX4_MOUSE (2-250): 4.49e-30: 117: 18.22		ALX4_MOUSE (29-328): 9.59e-32: 124: 17.93
+	Hs
		453048 HXA5_HUMAN (7-249): 5.95e-32: 119: 24.32		HXB7_HUMAN (43-271): 4.77e-32: 120: 21.83
+	Mm
		192290 ALX4_MOUSE (2-250): 4.49e-30: 117: 18.22		PO3F4_MOUSE (1-269): 9.37e-31: 120: 15.61
+	Hs
		453052 HXA7_HUMAN (8-248): 2.61e-31: 117: 25.73		HXB7_HUMAN (43-271): 4.77e-32: 120: 21.83
+	Hs
		446864 HXA5_HUMAN (7-249): 5.95e-32: 119: 24.32		HXD4_HUMAN (62-301): 8.84e-30: 115: 23.33
+	Hs
		567821 HXA1_HUMAN (10-247): 1.1e-30: 118: 24.17		HXB9_HUMAN (17-266): 8.84e-30: 115: 18.00
+	Hs
		882139 GSC_HUMAN (13-245): 6.77e-34: 124: 20.60		ZFHX4_HUMAN (163-287): 8.25e-12: 68.5: 17.19