HitPredict

Interactor 1: SMUF2 (A2A5Z6)
E3 ubiquitin-protein ligase SMURF2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: Smurf2

Interactor 2: SMAD7 (O35253)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
Gene: SMAD7

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25885904, 25612247, 15173588
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway GO:0030514 - negative regulation of BMP signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Mm			1 426
+	Hs
		167394 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD7_HUMAN (1-426): 1.17e-170: 486: 98.12
+	Hs
		206976 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD6_HUMAN (1-425): 2.65e-149: 434: 42.86
+	Mm
		192495 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD7_MOUSE (1-426): 2.57e-175: 498: 100.00
+	Mm
		56826 SMUF2_MOUSE (1-748): 0: 837: 100.00		SMAD1_MOUSE (79-424): 6.87e-141: 412: 23.80
+	Hs
		1305886 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD5_HUMAN (79-424): 3.99e-141: 413: 24.08
+	Hs
		950287 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD3_HUMAN (81-424): 8.58e-142: 413: 25.95
+	Hs
		1078760 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD1_HUMAN (79-424): 8.73e-141: 412: 23.80
+	Hs
		1078667 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46
+	Hs
		167395 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD7_HUMAN (1-426): 1.17e-170: 486: 98.12
+	Mm
		192368 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD6_MOUSE (1-425): 2.05e-145: 424: 42.19
+	Hs
		206977 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD6_HUMAN (1-425): 2.65e-149: 434: 42.86
+	Mm
		936618 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD1_MOUSE (79-424): 6.87e-141: 412: 23.80
+	Xl
		945613 SMUF1_XENLA (1-748): 0: 745: 70.77		P79947_XENLA (79-424): 6.28e-142: 414: 23.85
+	Hs
		1305888 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD5_HUMAN (79-424): 3.99e-141: 413: 24.08
+	Hs
		950291 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD3_HUMAN (81-424): 8.58e-142: 413: 25.95
+	Hs
		1078761 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD1_HUMAN (79-424): 8.73e-141: 412: 23.80
+	Hs
		1078671 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46
+	Mm
		1143948 ITCH_MOUSE (1-748): 0: 667: 32.34		SMAD2_MOUSE (82-424): 1.08e-136: 401: 24.29
+	Hs
		1035596 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD4_HUMAN (54-259): 1.52e-41: 156: 22.28
+	Hs
		1035600 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD4_HUMAN (54-259): 1.52e-41: 156: 22.28