HitPredict

Interactor 1: ATF7 (P17544)
Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)
Gene: ATF7

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29844126
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 2517
+	Hs
		973616 CREB5_HUMAN (1-433): 5.82e-65: 220: 36.92		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		402371 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		579158 ATF1_HUMAN (110-383): 5.11e-32: 125: 15.33		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		556952 CREB1_HUMAN (89-383): 4.8e-27: 112: 15.25		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		401617 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		579320 ATF6A_HUMAN (124-392): 1.83e-28: 120: 20.07		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		401362 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		MUC1_HUMAN (290-979): 5.97e-38: 159: 15.12
+	Hs
		568076 JUND_HUMAN (94-408): 1.06e-26: 112: 16.67		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Mm
		818691 ATF1_MOUSE (110-383): 1.03e-27: 113: 14.96		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Mm
		818697 CREB1_MOUSE (89-383): 3.06e-27: 113: 15.25		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Ce
		105502 JUN_CAEEL (133-400): 7.06e-30: 120: 17.04		EGL13_CAEEL (1033-1238): 1.27e-41: 163: 20.00
+	Mm
		404137 JUN_MOUSE (94-409): 9.15e-45: 161: 15.74		SOX8_MOUSE (1104-1201): 2.48e-25: 114: 32.65
+	Hs
		402007 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		402682 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		818823 CR3L4_HUMAN (137-460): 1.67e-31: 126: 12.50		SOX9_HUMAN (1031-1201): 1.04e-24: 112: 23.08
+	Hs
		402260 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		KMT2C_HUMAN (1873-2516): 1.5e-09: 66.4: 10.57
+	Mm
		964088 CREB1_MOUSE (89-383): 3.06e-27: 113: 15.25		SOX9_MOUSE (1031-1201): 4.76e-25: 114: 23.08
+	Hs
		401830 JUN_HUMAN (94-409): 4.25e-45: 162: 15.89		MAP1A_HUMAN (763-2517): 4.52e-09: 64.4: 8.00