HitPredict

Interactor 1: SMUF2 (A2A5Z6)
E3 ubiquitin-protein ligase SMURF2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: Smurf2

Interactor 2: DVL2 (Q60838)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19379695
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Mm			1 736
+	Hs
		151200 SMUF2_HUMAN (1-748): 0: 835: 99.20		DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60
+	Mm
		56824 SMUF2_MOUSE (1-748): 0: 837: 100.00		DVL1_MOUSE (11-736): 7.31e-159: 478: 58.27
+	Mm
		1141509 SMUF1_MOUSE (1-748): 0: 753: 72.61		DVL2_MOUSE (13-736): 0: 541: 100.00
+	Hs
		151206 SMUF1_HUMAN (1-748): 0: 741: 70.05		DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60
+	Hs
		150684 NEDD4_HUMAN (88-746): 0: 637: 34.12		DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40
+	Hs
		1192152 HUWE1_HUMAN (123-747): 0: 588: 31.44		DVL3_HUMAN (11-736): 3.14e-153: 464: 64.50
+	Hs
		150725 HUWE1_HUMAN (123-747): 0: 588: 31.44		DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40
+	Mm
		808344 NEDD4_MOUSE (7-746): 0: 703: 34.64		DLG3_MOUSE (75-536): 7.34e-45: 175: 17.01
+	Ce
		1094742 Q9BKW4_CAEEL (243-746): 0: 592: 45.60		MIG5_CAEEL (12-561): 1e-72: 251: 25.71
+	Mm
		93267 E9PXB7_MOUSE (102-746): 0: 639: 40.18		DLG3_MOUSE (75-536): 7.34e-45: 175: 17.01
+	Hs
		1021523 HUWE1_HUMAN (123-747): 0: 588: 31.44		DLG1_HUMAN (95-708): 2.54e-46: 179: 15.96
+	Mm
		93273 E9PXB7_MOUSE (102-746): 0: 639: 40.18		DLG4_MOUSE (199-494): 3.53e-22: 103: 15.82
+	Hs
		151146 NED4L_HUMAN (5-369): 2.5e-33: 139: 15.00		DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60
+	Hs
		151140 ITCH_HUMAN (1-373): 1.89e-28: 124: 17.92		DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60
+	Hs
		124996 WWP2_HUMAN (1-361): 3.66e-27: 120: 17.99		DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60
+	Hs
		1273604 ITCH_HUMAN (1-373): 1.89e-28: 124: 17.92		DVL3_HUMAN (11-736): 3.14e-153: 464: 64.50
+	Hs
		150747 ITCH_HUMAN (1-373): 1.89e-28: 124: 17.92		DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40
+	Hs
		124995 WWP2_HUMAN (1-361): 3.66e-27: 120: 17.99		DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40
+	Mm
		1143429 NED4L_MOUSE (5-369): 8.19e-33: 138: 14.70		DLG4_MOUSE (199-494): 3.53e-22: 103: 15.82
+	Hs
		1271021 NED4L_HUMAN (5-369): 2.5e-33: 139: 15.00		DLG3_HUMAN (151-553): 1.98e-18: 92.2: 13.69