HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: KAP3 (P31323)
cAMP-dependent protein kinase type II-beta regulatory subunit
Gene: PRKAR2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 26186194, 26496610, 21795691, 28514442, 31189917, 32296183, 24981860, 33961781, 27107012, 33957083, 35271311, 32707033, 30274258, 23455922, 17148597, unassigned1304, 25477193
Identification Methods affinity chromatography technology, protein complementation assay, two hybrid, proximity labelling technology, pull down, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, barcode fusion genetics two hybrid, validated two hybrid and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005952 - cAMP-dependent protein kinase complex
and 7 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 351
Hs

1 418
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Last updated: 15 Jul 2024