HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33957083
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 457
+	Hs
		610723 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609666 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609664 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		682173 AKT2_HUMAN (18-343): 1.61e-150: 434: 38.79		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		681830 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035058 AKT3_HUMAN (37-347): 2.7e-148: 428: 41.59		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035034 KS6B2_HUMAN (7-351): 3.64e-142: 412: 34.08		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		850786 PRKX_HUMAN (3-351): 1.15e-143: 412: 48.43		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		969070 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1035006 SGK2_HUMAN (43-340): 5.31e-137: 395: 43.56		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		217878 PRKY_HUMAN (33-267): 8.27e-92: 277: 52.77		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		117002 SGK1_HUMAN (34-342): 1.03e-85: 267: 42.54		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118692 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118712 PRKX_HUMAN (3-351): 1.15e-143: 412: 48.43		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		568664 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		609671 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		118793 SGK2_HUMAN (43-340): 5.31e-137: 395: 43.56		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		609649 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1053243 KS6B2_HUMAN (7-351): 3.64e-142: 412: 34.08		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Rn
		193486 AKT3_RAT (37-343): 8.56e-147: 424: 42.12		STIP1_RAT (265-457): 1.25e-22: 102: 18.14