HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: CK5P2 (Q96SN8)
CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)
Gene: CDK5RAP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	29162697, 35271311, 32707033, 30274258, 23455922, 35709258
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 1893
+	Hs
		610771 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		CK5P2_HUMAN (1-1893): 4.16e-171: 572: 100.00
+	Hs
		518814 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		TPR_HUMAN (1-749): 1.76e-27: 124: 10.95
+	Hs
		568567 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH9_HUMAN (1076-1870): 2.72e-24: 114: 10.17
+	Hs
		568700 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYOME_HUMAN (50-1479): 6.18e-23: 109: 11.47
+	Hs
		610736 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYOME_HUMAN (50-1479): 6.18e-23: 109: 11.47
+	Hs
		610795 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH2_HUMAN (1169-1882): 5.05e-23: 109: 10.61
+	Hs
		609676 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		MYOME_HUMAN (50-1479): 6.18e-23: 109: 11.47
+	Hs
		610802 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH4_HUMAN (1156-1882): 1.02e-19: 99.2: 11.08
+	Hs
		551616 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		DESP_HUMAN (35-576): 3.93e-27: 123: 16.16
+	Mm
		933112 KAPCB_MOUSE (1-351): 5.81e-161: 455: 92.31		MYOME_MOUSE (25-1161): 4.31e-19: 96.9: 10.90
+	Hs
		568568 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH10_HUMAN (1278-1866): 8.19e-15: 83: 11.48
+	Mm
		554927 KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70		MYH7_MOUSE (1-696): 1.99e-28: 127: 11.41
+	Hs
		681696 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		MYH9_HUMAN (1076-1870): 2.72e-24: 114: 10.17
+	Hs
		551672 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		DESP_HUMAN (35-576): 3.93e-27: 123: 16.16
+	Hs
		522538 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH1_HUMAN (884-1666): 1.1e-12: 76.1: 12.50
+	Hs
		528359 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH6_HUMAN (864-1654): 3.35e-11: 71.1: 11.49
+	Hs
		724784 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		MYH9_HUMAN (1076-1870): 2.72e-24: 114: 10.17
+	Dm
		397193 KPC1_DROME (3-351): 3.07e-140: 414: 36.11		MYSN_DROME (161-1048): 2.84e-21: 104: 12.85
+	Mm
		554901 KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70		MYH6_MOUSE (864-1654): 5.98e-11: 70.3: 11.61
+	Hs
		116964 SGK1_HUMAN (34-342): 1.03e-85: 267: 42.54		MYH1_HUMAN (884-1666): 1.1e-12: 76.1: 12.50