HitPredict - High confidence protein-protein interactions

Interactor 1: CEBPB (P17676)
CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
Gene: CEBPB

Interactor 2: ATF4 (P18848)
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
Gene: ATF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	30884312, 20102225
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding and 20 others more... GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0006366 - transcription by RNA polymerase II GO:0030182 - neuron differentiation GO:0034976 - response to endoplasmic reticulum stress GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070169 - positive regulation of biomineral tissue development GO:0090575 - RNA polymerase II transcription regulator complex GO:0140467 - integrated stress response signaling GO:1990837 - sequence-specific double-stranded DNA binding GO:2000120 - positive regulation of sodium-dependent phosphate transport
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	345
Hs

1	351

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Last updated: 15 Jul 2024