HitPredict

Interactor 1: HLAG (P17693)
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]
Gene: HLA-G

Interactor 2: NKG2A (P26715)
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Gene: KLRC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32575403
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0001915 - negative regulation of T cell mediated cytotoxicity GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0045953 - negative regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 338 Hs			1 233
+	Hs
		354302 HLAB_HUMAN (1-315): 2.46e-151: 431: 81.91		NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00
+	Hs
		533124 HLAE_HUMAN (20-333): 1.68e-142: 408: 77.39		NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00
+	Hs
		533125 HLAE_HUMAN (20-333): 1.68e-142: 408: 77.39		NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68
+	Hs
		59726 HLAA_HUMAN (1-338): 6.41e-166: 468: 82.84		KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05
+	Hs
		382559 HLAA_HUMAN (1-338): 6.41e-166: 468: 82.84		CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51
+	Hs
		382561 HLAA_HUMAN (1-338): 6.41e-166: 468: 82.84		CLC4A_HUMAN (34-231): 2.26e-41: 142: 16.81
+	Hs
		382490 HLAA_HUMAN (1-338): 6.41e-166: 468: 82.84		CLC4D_HUMAN (53-232): 2.6e-40: 139: 15.24
+	Hs
		382491 HLAA_HUMAN (1-338): 6.41e-166: 468: 82.84		CLC2B_HUMAN (80-233): 3.14e-40: 137: 25.64
+	Hs
		354602 HLAB_HUMAN (1-315): 2.46e-151: 431: 81.91		CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51
+	Hs
		354435 HLAB_HUMAN (1-315): 2.46e-151: 431: 81.91		KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35
+	Hs
		59727 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05
+	Hs
		488420 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51
+	Hs
		488205 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35
+	Hs
		488421 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		CLC4A_HUMAN (34-231): 2.26e-41: 142: 16.81
+	Hs
		488317 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		CLC4D_HUMAN (53-232): 2.6e-40: 139: 15.24
+	Hs
		673960 HLAF_HUMAN (4-338): 2.51e-142: 407: 79.10		CL12B_HUMAN (113-231): 1.89e-44: 151: 31.01
+	Hs
		488322 HLAC_HUMAN (1-311): 5.22e-147: 420: 82.32		CLC2B_HUMAN (80-233): 3.14e-40: 137: 25.64
+	Hs
		533144 HLAE_HUMAN (20-333): 1.68e-142: 408: 77.39		KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35
+	Hs
		533155 HLAE_HUMAN (20-333): 1.68e-142: 408: 77.39		CLC2B_HUMAN (80-233): 3.14e-40: 137: 25.64
+	Hs
		673971 HLAF_HUMAN (4-338): 2.51e-142: 407: 79.10		CLC2B_HUMAN (80-233): 3.14e-40: 137: 25.64