HitPredict

Interactor 1: HLAG (P17693)
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]
Gene: HLA-G

Interactor 2: LIRB1 (Q8NHL6)
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
Gene: LILRB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 12853576, 24018270, 16455647, 19583775
Identification Methods pull down, surface plasmon resonance, comigration in non denaturing gel electrophoresis, molecular sieving, affinity technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~ig, C1-set~Ig_2, MHC_I~ig
Common GO terms GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0002767 - immune response-inhibiting cell surface receptor signaling pathway
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
GO:0042130 - negative regulation of T cell proliferation
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 338
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024