HitPredict

Interactor 1: PTN2 (P17706)
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
Gene: PTPN2

Interactor 2: C5AR2 (Q9P296)
C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77)
Gene: C5AR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 337
+	Hs
		573596 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		APJ_HUMAN (26-336): 6.02e-67: 216: 23.21
+	Hs
		573956 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		C5AR2_HUMAN (1-337): 1.47e-65: 211: 100.00
+	Hs
		573570 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		C5AR1_HUMAN (3-336): 2.69e-63: 206: 34.48
+	Hs
		665837 PTN6_HUMAN (2-351): 4.45e-132: 393: 27.78		CXCR4_HUMAN (2-298): 9.99e-72: 228: 22.58
+	Hs
		665802 PTN6_HUMAN (2-351): 4.45e-132: 393: 27.78		SSR2_HUMAN (12-336): 3.91e-67: 216: 19.59
+	Hs
		796449 PTN9_HUMAN (4-277): 3.68e-121: 365: 37.11		C5AR2_HUMAN (1-337): 1.47e-65: 211: 100.00
+	Hs
		783810 PTN9_HUMAN (4-277): 3.68e-121: 365: 37.11		CCR2_HUMAN (5-316): 2.35e-61: 202: 18.15
+	Hs
		570539 PTN2_HUMAN (1-415): 2.43e-175: 497: 100.00		C3AR_HUMAN (168-334): 3.05e-09: 60.1: 25.54
+	Hs
		208447 PTPRD_HUMAN (17-276): 6.69e-108: 351: 32.45		OX2R_HUMAN (2-333): 5.5e-62: 205: 13.85
+	Hs
		573717 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		C3AR_HUMAN (168-334): 3.05e-09: 60.1: 25.54
+	Hs
		441192 PTPRC_HUMAN (2-326): 8.27e-80: 269: 23.37		CXCR4_HUMAN (2-298): 9.99e-72: 228: 22.58
+	Hs
		616954 PTPRD_HUMAN (17-276): 6.69e-108: 351: 32.45		LPAR6_HUMAN (41-314): 2.45e-15: 77.8: 21.50
+	Hs
		895613 PTN11_HUMAN (32-272): 1.6e-47: 172: 39.00		CXCR4_HUMAN (2-298): 9.99e-72: 228: 22.58