HitPredict

Interactor 1: FRPD4 (A2AFR3)
FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)
Gene: Frmpd4

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36417873, 36604605
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0014069 - postsynaptic density GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1320 Mm			1 724
+	Hs
		942344 FRPD4_HUMAN (1-1320): 0: 2164: 90.70		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		1062034 FRPD4_HUMAN (1-1320): 0: 2164: 90.70		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Hs
		1021493 FRPD4_HUMAN (1-1320): 0: 2164: 90.70		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		1049949 FRPD4_HUMAN (1-1320): 0: 2164: 90.70		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Mm
		710140 FAK1_MOUSE (201-542): 7.07e-71: 260: 22.44		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		942340 FAK2_HUMAN (191-528): 5.22e-69: 254: 21.23		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Mm
		3560 A0A140LIW3_MOUSE (776-938): 4.96e-61: 232: 44.71		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		1052831 FAK2_HUMAN (191-528): 5.22e-69: 254: 21.23		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Mm
		1143406 Q8BXG0_MOUSE (193-320): 1.01e-43: 156: 53.91		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143518 MAGI3_MOUSE (14-161): 1.04e-36: 153: 23.40		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		1049972 FRPD1_HUMAN (62-539): 5.36e-146: 484: 48.96		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		990892 ZO1_HUMAN (69-271): 3.07e-38: 158: 15.91		DLG5_HUMAN (40-245): 4.01e-17: 88.6: 31.55
+	Hs
		1232496 MAGI1_HUMAN (14-158): 1.62e-25: 117: 17.50		PALS1_HUMAN (22-196): 1.91e-13: 75.9: 14.21
+	Hs
		1050087 ZO2_HUMAN (70-189): 1.37e-12: 74.8: 18.57		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		1255142 ZO2_HUMAN (70-189): 1.37e-12: 74.8: 18.57		DLG5_HUMAN (40-245): 4.01e-17: 88.6: 31.55