HitPredict - High confidence protein-protein interactions

Interactor 1: ACHB2 (P17787)
Neuronal acetylcholine receptor subunit beta-2
Gene: CHRNB2

Interactor 2: ACHA4 (P43681)
Neuronal acetylcholine receptor subunit alpha-4
Gene: CHRNA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.831

Property	Details
Experiments	26801076, 12527804, 29720657
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, 3D electron microscopy, molecular sieving
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Neur_chan_LBD~Neur_chan_LBD, Neur_chan_LBD~Neur_chan_memb, Neur_chan_memb~Neur_chan_memb
Common GO terms	GO:0001666 - response to hypoxia GO:0005886 - plasma membrane GO:0005892 - acetylcholine-gated channel complex GO:0006811 - monoatomic ion transport GO:0006816 - calcium ion transport and 19 others more... GO:0007165 - signal transduction GO:0007271 - synaptic transmission, cholinergic GO:0009897 - external side of plasma membrane GO:0014059 - regulation of dopamine secretion GO:0015276 - ligand-gated monoatomic ion channel activity GO:0015464 - acetylcholine receptor activity GO:0016020 - membrane GO:0019233 - sensory perception of pain GO:0022848 - acetylcholine-gated monoatomic cation-selective channel activity GO:0035094 - response to nicotine GO:0035095 - behavioral response to nicotine GO:0042113 - B cell activation GO:0042166 - acetylcholine binding GO:0043005 - neuron projection GO:0045202 - synapse GO:0050877 - nervous system process GO:0050890 - cognition GO:0051899 - membrane depolarization GO:0095500 - acetylcholine receptor signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	502
Hs

1	627

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Last updated: 15 Jul 2024