Interactor 1: EGLN (P17813)
Endoglin (CD antigen CD105)
Gene: ENG
Interactor 2: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 0.60 | 0.738 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12015308, 18974388, 9872992, 15702480, 23868260, 16785228 |
| Identification Methods | affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, in-gel kinase assay |
| Interaction Type | physical association, direct interaction, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0001837 - epithelial to mesenchymal transition GO:0001937 - negative regulation of endothelial cell proliferation GO:0003222 - ventricular trabecula myocardium morphogenesis GO:0005024 - transforming growth factor beta receptor activity GO:0005114 - type II transforming growth factor beta receptor binding and 15 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs |  |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm |  |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
