HitPredict

Interactor 1: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Interactor 2: DUX4 (Q9UBX2)
Double homeobox protein 4 (Double homeobox protein 10)
Gene: DUX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	26816005
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 614 Hs			1 424
+	Hs
		78153 B5BUE6_HUMAN (1-614): 0: 623: 99.84		DUX4_HUMAN (1-424): 1.09e-57: 196: 100.00
+	Hs
		571495 DDX5_HUMAN (1-614): 0: 624: 100.00		DUX4C_HUMAN (1-374): 2.41e-42: 154: 94.12
+	Hs
		78152 B5BUE6_HUMAN (1-614): 0: 623: 99.84		DUX4C_HUMAN (1-374): 2.41e-42: 154: 94.12
+	Hs
		1271688 DDX17_HUMAN (30-612): 0: 534: 66.83		DUX4_HUMAN (1-424): 1.09e-57: 196: 100.00
+	Hs
		1123931 Q59F66_HUMAN (30-602): 6.42e-176: 518: 66.72		DUX4_HUMAN (1-424): 1.09e-57: 196: 100.00
+	Mm
		1207261 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		Q8VD35_MOUSE (13-95): 4.78e-11: 65: 31.33
+	Hs
		134238 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		DUX4_HUMAN (1-424): 1.09e-57: 196: 100.00
+	Mm
		1119388 DDX17_MOUSE (30-612): 0: 536: 66.67		Q8VD35_MOUSE (13-95): 4.78e-11: 65: 31.33
+	Hs
		686564 DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68		OTX2_HUMAN (13-95): 2.96e-11: 65.8: 31.33