HitPredict

Interactor 1: XBP1 (P17861)
X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]
Gene: XBP1

Interactor 2: ATF6A (P18850)
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
Gene: ATF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 23661758, 20102225
Identification Methods fluorescent resonance energy transfer, peptide array
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains bZIP_1~bZIP_2
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
and 15 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 261
Hs

1 670
+ Hs
+ Hs
+ Ce
+ Mb
+ Hs
+ Hs
+ Hs
+ At
+ At
+ Hs
+ At
+ Dm
+ At
+ At
+ At
+ At
+ Hs
+ At
+ At

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Last updated: 15 Jul 2024