HitPredict

Interactor 1: PCNA (P17917)
Proliferating cell nuclear antigen (PCNA) (Cyclin) (Mutagen-sensitive 209 protein)
Gene: PCNA

Interactor 2: Q9VKW3 (Q9VKW3)
Replication factor C subunit 3 (SD11293p)
Gene: RfC3

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~PCNA_C, AAA~PCNA_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006261 - DNA-templated DNA replication GO:0006272 - leading strand elongation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 260 Dm			1 332
+	Hs
		517114 PCNA_HUMAN (1-259): 9.94e-111: 321: 71.04		RFC5_HUMAN (4-331): 3.23e-95: 287: 60.67
+	Hs
		517099 PCNA_HUMAN (1-259): 9.94e-111: 321: 71.04		RFC4_HUMAN (2-322): 1.11e-91: 279: 39.70
+	Bt
		985516 PCNA_BOVIN (1-259): 2.62e-111: 322: 71.04		RFC2_BOVIN (10-322): 4.66e-87: 267: 37.26
+	Hs
		517100 PCNA_HUMAN (1-259): 9.94e-111: 321: 71.04		RFC2_HUMAN (10-322): 1.36e-85: 263: 36.31
+	Bt
		1100598 PCNA_BOVIN (1-259): 2.62e-111: 322: 71.04		Q29RS9_BOVIN (2-322): 8.32e-81: 250: 38.07
+	Dm
		572231 PCNA_DROME (1-260): 9.56e-112: 323: 100.00		Q9VX15_DROME (7-317): 5.23e-77: 241: 35.09
+	Sc
		550541 PCNA_YEAST (1-259): 8.69e-93: 275: 35.91		RFC3_YEAST (1-321): 1.59e-84: 260: 47.11
+	Hs
		517115 PCNA_HUMAN (1-259): 9.94e-111: 321: 71.04		RFC3_HUMAN (12-331): 3.49e-66: 213: 22.86
+	Dm
		572184 PCNA_DROME (1-260): 9.56e-112: 323: 100.00		Q7KLW6_DROME (12-331): 2.18e-60: 199: 24.57
+	Sc
		550554 PCNA_YEAST (1-259): 8.69e-93: 275: 35.91		RFC2_YEAST (6-322): 2.25e-77: 242: 35.03
+	Sc
		550553 PCNA_YEAST (1-259): 8.69e-93: 275: 35.91		RFC4_YEAST (1-321): 1.26e-74: 234: 38.39
+	Hs
		238258 RAD1_HUMAN (2-260): 2.43e-65: 206: 16.18		RFC5_HUMAN (4-331): 3.23e-95: 287: 60.67
+	Hs
		238255 RAD1_HUMAN (2-260): 2.43e-65: 206: 16.18		RFC4_HUMAN (2-322): 1.11e-91: 279: 39.70
+	Sc
		550539 PCNA_YEAST (1-259): 8.69e-93: 275: 35.91		RFC5_YEAST (12-326): 1.43e-60: 199: 22.95
+	Hs
		238259 RAD1_HUMAN (2-260): 2.43e-65: 206: 16.18		RFC3_HUMAN (12-331): 3.49e-66: 213: 22.86