HitPredict

Interactor 1: SPI1 (P17947)
Transcription factor PU.1 (31 kDa-transforming protein)
Gene: SPI1

Interactor 2: GATA2 (P23769)
Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Gene: GATA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.690

The method score is based on:

Property Details
Experiments 18250304, 10411939, 10364157
Identification Methods affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003682 - chromatin binding
GO:0003700 - DNA-binding transcription factor activity
and 7 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 270
Hs

1 480
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Last updated: 15 Jul 2024