HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	20805333, 7657594
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1338 Hs			1 724
+	Hs
		655241 VGFR3_HUMAN (21-1330): 0: 755: 37.92		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129225 VGFR3_HUMAN (21-1330): 0: 755: 37.92		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		433247 VGFR1_HUMAN (1-1338): 0: 995: 100.00		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Mm
		643062 RET_MOUSE (802-1180): 4.02e-77: 280: 41.16		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		557041 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		601463 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		403533 KIT_MOUSE (19-668): 5.73e-54: 207: 16.52		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		609182 FGFR3_HUMAN (1-353): 3.63e-53: 203: 11.78		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		499235 KIT_HUMAN (19-668): 2.82e-52: 202: 16.42		P85A_HUMAN (1-724): 0: 596: 100.00
+	Dm
		112205 M9MRE1_DROME (26-1326): 0: 646: 20.92		M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78
+	Hs
		129191 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Dm
		186281 Q8IPG1_DROME (26-1326): 0: 648: 20.99		O18683_DROME (319-465): 9.73e-10: 63.5: 20.95
+	Hs
		129199 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129178 KIT_HUMAN (19-668): 2.82e-52: 202: 16.42		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129176 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		557215 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		499280 KIT_HUMAN (19-668): 2.82e-52: 202: 16.42		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		433226 KIT_HUMAN (19-668): 2.82e-52: 202: 16.42		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Mm
		140055 KIT_MOUSE (19-668): 5.73e-54: 207: 16.52		P85B_MOUSE (287-439): 8.37e-12: 70.8: 23.38
+	Mm
		403538 KIT_MOUSE (19-668): 5.73e-54: 207: 16.52		MATK_MOUSE (617-721): 2.52e-11: 68.7: 24.53