HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10749680
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0008284 - positive regulation of cell population proliferation GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1338 Hs			1 583
+	Hs
		572619 VGFR1_HUMAN (1-1338): 0: 995: 100.00		SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88
+	Hs
		666022 VGFR3_HUMAN (21-1330): 0: 755: 37.92		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		572588 VGFR1_HUMAN (1-1338): 0: 995: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Dm
		112229 M9MRE1_DROME (26-1326): 0: 646: 20.92		Q9V3C8_DROME (128-581): 3.26e-84: 270: 36.56
+	Hs
		557624 VGFR3_HUMAN (21-1330): 0: 755: 37.92		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		655241 VGFR3_HUMAN (21-1330): 0: 755: 37.92		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		129225 VGFR3_HUMAN (21-1330): 0: 755: 37.92		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		729258 VGFR3_HUMAN (21-1330): 0: 755: 37.92		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Dm
		112231 M9MRE1_DROME (26-1326): 0: 646: 20.92		SRC42_DROME (351-579): 6.25e-40: 154: 18.07
+	Dm
		186281 Q8IPG1_DROME (26-1326): 0: 648: 20.99		O18683_DROME (462-581): 1.36e-15: 81.8: 28.00
+	Dm
		112212 M9MRE1_DROME (26-1326): 0: 646: 20.92		CSW_DROME (483-579): 2.71e-12: 71.8: 27.72
+	Mm
		643062 RET_MOUSE (802-1180): 4.02e-77: 280: 41.16		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Mm
		524116 CNTN1_MOUSE (1-744): 1.72e-61: 231: 12.44		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Mm
		643644 PGFRA_MOUSE (6-666): 9.16e-61: 229: 19.85		SHB_MOUSE (369-579): 3.37e-41: 157: 20.18
+	Hs
		557041 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		601463 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		557215 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129191 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129199 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		557088 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48