HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 25387128, 12796773
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, ig~I-set, I-set~Ig_2, ig~ig, Ig_2~ig, Ig_3~I-set, Ig_3~ig, Ig_2~Ig_3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, VEGFR-2_TMD~VEGFR-2_TMD
Common GO terms GO:0001525 - angiogenesis
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005021 - vascular endothelial growth factor receptor activity
GO:0005524 - ATP binding
GO:0005768 - endosome
and 14 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1338
Hs

1 1356
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Last updated: 15 Jul 2024