HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: PLGF (P49763)
Placenta growth factor (PlGF)
Gene: PGF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	9452434, 8700872, 14684734, 20660291
Identification Methods	pull down, coimmunoprecipitation, x-ray crystallography, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDGF~ig, Ig_3~PDGF
Common GO terms	GO:0005615 - extracellular space GO:0008284 - positive regulation of cell population proliferation GO:0030154 - cell differentiation GO:0045766 - positive regulation of angiogenesis GO:0048010 - vascular endothelial growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1338 Hs			1 221
+	Hs
		572600 VGFR1_HUMAN (1-1338): 0: 995: 100.00		VEGFB_HUMAN (36-192): 9.1e-52: 168: 32.48
+	Mm
		729710 VGFR1_MOUSE (1-1337): 0: 985: 81.54		PLGF_MOUSE (1-140): 6.91e-56: 176: 63.12
+	Mm
		729711 VGFR1_MOUSE (1-1337): 0: 985: 81.54		VEGFB_MOUSE (25-191): 1.99e-52: 169: 30.36
+	Hs
		549553 VGFR1_HUMAN (1-1338): 0: 995: 100.00		VEGFA_HUMAN (24-143): 1.99e-45: 156: 44.17
+	Mm
		729713 VGFR1_MOUSE (1-1337): 0: 985: 81.54		VEGFA_MOUSE (24-143): 1.83e-42: 149: 44.17
+	Mm
		729406 VGFR3_MOUSE (21-1323): 0: 759: 37.90		VEGFC_MOUSE (5-155): 1.02e-50: 171: 23.87
+	Hs
		729247 VGFR3_HUMAN (21-1330): 0: 755: 37.92		VEGFC_HUMAN (5-155): 1.76e-48: 165: 22.64
+	Hs
		217378 VGFR3_HUMAN (21-1330): 0: 755: 37.92		VEGFD_HUMAN (5-149): 3.71e-44: 152: 24.32
+	Dm
		1182097 Q7KTI7_DROME (26-1326): 0: 649: 21.29		Q9BLX1_DROME (47-149): 1.94e-32: 121: 22.64
+	Dm
		112227 M9MRE1_DROME (26-1326): 0: 646: 20.92		Q9BLX1_DROME (47-149): 1.94e-32: 121: 22.64
+	Hs
		350950 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		PDGFB_HUMAN (30-159): 5.25e-40: 138: 21.58
+	Hs
		557261 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		PDGFC_HUMAN (20-133): 2.95e-37: 134: 20.16
+	Hs
		729626 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFC_HUMAN (5-155): 1.76e-48: 165: 22.64
+	Hs
		549560 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFA_HUMAN (24-143): 1.99e-45: 156: 44.17
+	Hs
		217379 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFD_HUMAN (5-149): 3.71e-44: 152: 24.32
+	Hs
		350948 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		PDGFB_HUMAN (30-159): 5.25e-40: 138: 21.58
+	Hs
		376364 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		PDGFA_HUMAN (42-130): 1.03e-25: 101: 20.21
+	Hs
		452486 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		PDGFC_HUMAN (20-133): 2.95e-37: 134: 20.16
+	Mm
		729414 VGFR2_MOUSE (2-416): 5.2e-43: 173: 11.98		VEGFA_MOUSE (24-143): 1.83e-42: 149: 44.17
+	Hs
		376361 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		PDGFA_HUMAN (42-130): 1.03e-25: 101: 20.21