HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: VEGFB (P49765)
Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
Gene: VEGFB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	9751730, 10409677
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PDGF~ig, Ig_3~PDGF
Common GO terms	GO:0005615 - extracellular space GO:0045766 - positive regulation of angiogenesis GO:0048010 - vascular endothelial growth factor receptor signaling pathway GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1338 Hs			1 207
+	Mm
		729711 VGFR1_MOUSE (1-1337): 0: 985: 81.54		VEGFB_MOUSE (1-207): 7.9e-75: 226: 86.96
+	Hs
		572599 VGFR1_HUMAN (1-1338): 0: 995: 100.00		PLGF_HUMAN (3-177): 2.7e-66: 205: 31.35
+	Hs
		549553 VGFR1_HUMAN (1-1338): 0: 995: 100.00		VEGFA_HUMAN (18-140): 4.11e-43: 150: 38.71
+	Mm
		729710 VGFR1_MOUSE (1-1337): 0: 985: 81.54		PLGF_MOUSE (4-131): 6.24e-48: 156: 30.53
+	Mm
		729713 VGFR1_MOUSE (1-1337): 0: 985: 81.54		VEGFA_MOUSE (18-140): 2.58e-41: 145: 39.52
+	Mm
		729406 VGFR3_MOUSE (21-1323): 0: 759: 37.90		VEGFC_MOUSE (1-146): 8.2e-47: 160: 24.34
+	Hs
		729247 VGFR3_HUMAN (21-1330): 0: 755: 37.92		VEGFC_HUMAN (15-146): 5.88e-47: 161: 25.36
+	Hs
		217378 VGFR3_HUMAN (21-1330): 0: 755: 37.92		VEGFD_HUMAN (4-140): 2.64e-47: 160: 25.53
+	Dm
		1182097 Q7KTI7_DROME (26-1326): 0: 649: 21.29		Q9BLX1_DROME (42-139): 6.04e-27: 106: 25.00
+	Dm
		112227 M9MRE1_DROME (26-1326): 0: 646: 20.92		Q9BLX1_DROME (42-139): 6.04e-27: 106: 25.00
+	Hs
		350950 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		PDGFB_HUMAN (45-150): 1.72e-33: 121: 29.41
+	Hs
		376364 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		PDGFA_HUMAN (37-141): 7.31e-31: 114: 22.52
+	Hs
		729626 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFC_HUMAN (15-146): 5.88e-47: 161: 25.36
+	Hs
		217379 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFD_HUMAN (4-140): 2.64e-47: 160: 25.53
+	Hs
		549560 VGFR2_HUMAN (2-438): 9.05e-45: 179: 12.15		VEGFA_HUMAN (18-140): 4.11e-43: 150: 38.71
+	Mm
		729414 VGFR2_MOUSE (2-416): 5.2e-43: 173: 11.98		VEGFA_MOUSE (18-140): 2.58e-41: 145: 39.52
+	Hs
		350948 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		PDGFB_HUMAN (45-150): 1.72e-33: 121: 29.41
+	Hs
		376361 PGFRB_HUMAN (25-560): 1.37e-48: 191: 20.73		PDGFA_HUMAN (37-141): 7.31e-31: 114: 22.52