HitPredict

Interactor 1: VGFR1 (P17948)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Gene: FLT1

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9790910, 10749680
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1338 Hs			1 582
+	Hs
		572589 VGFR1_HUMAN (1-1338): 0: 995: 100.00		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Hs
		433247 VGFR1_HUMAN (1-1338): 0: 995: 100.00		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		666022 VGFR3_HUMAN (21-1330): 0: 755: 37.92		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Hs
		572588 VGFR1_HUMAN (1-1338): 0: 995: 100.00		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Dm
		112229 M9MRE1_DROME (26-1326): 0: 646: 20.92		Q9V3C8_DROME (119-580): 3.81e-82: 265: 35.05
+	Hs
		557624 VGFR3_HUMAN (21-1330): 0: 755: 37.92		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Hs
		655241 VGFR3_HUMAN (21-1330): 0: 755: 37.92		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		729258 VGFR3_HUMAN (21-1330): 0: 755: 37.92		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Dm
		186281 Q8IPG1_DROME (26-1326): 0: 648: 20.99		O18683_DROME (458-580): 3.41e-36: 143: 30.95
+	Dm
		112212 M9MRE1_DROME (26-1326): 0: 646: 20.92		CSW_DROME (482-578): 4.65e-14: 77.6: 21.78
+	Hs
		601467 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Mm
		403421 RET_MOUSE (802-1180): 4.02e-77: 280: 41.16		SRC_MOUSE (341-573): 3.33e-38: 149: 15.98
+	Mm
		524116 CNTN1_MOUSE (1-744): 1.72e-61: 231: 12.44		ANS1B_MOUSE (26-366): 5.11e-50: 188: 14.01
+	Mm
		643062 RET_MOUSE (802-1180): 4.02e-77: 280: 41.16		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		557172 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		SHF_HUMAN (360-578): 3.1e-35: 139: 21.05
+	Hs
		522773 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Hs
		557041 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		601463 FGFR2_HUMAN (16-348): 8.87e-56: 211: 11.20		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		557215 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01
+	Hs
		557088 PGFRA_HUMAN (11-666): 1.05e-59: 226: 19.41		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07