HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: UBXN1 (Q04323)
UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)
Gene: UBXN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 297
+	Hs
		906948 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		FAF1_HUMAN (71-294): 1.76e-41: 153: 22.12
+	Mm
		967687 TERA_MOUSE (162-434): 9.21e-77: 256: 35.17		UBXN1_MOUSE (1-297): 3.84e-69: 218: 92.93
+	Hs
		874846 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBXN1_HUMAN (1-297): 5.45e-68: 215: 100.00
+	Ce
		873015 TERA2_CAEEL (19-419): 2.35e-75: 252: 26.42		UBXN1_CAEEL (4-293): 1.8e-49: 167: 28.12
+	Ce
		712422 TERA2_CAEEL (19-419): 2.35e-75: 252: 26.42		UBXN4_CAEEL (17-294): 1.48e-46: 164: 24.20
+	Hs
		875167 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBXN4_HUMAN (22-293): 5.83e-45: 160: 24.30
+	Hs
		299344 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBXN7_HUMAN (45-294): 2.33e-43: 156: 17.13
+	Hs
		875432 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		FAF1_HUMAN (71-294): 1.76e-41: 153: 22.12
+	Mm
		872336 TERA_MOUSE (162-434): 9.21e-77: 256: 35.17		FAF1_MOUSE (71-294): 1.1e-40: 151: 22.12
+	Sc
		636608 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		UBX7_YEAST (93-293): 8.71e-35: 132: 23.76
+	Sc
		636779 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		UBX3_YEAST (78-293): 1.42e-34: 132: 13.73
+	Hs
		875190 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBP13_HUMAN (2-162): 3.18e-36: 139: 22.98
+	Sc
		636664 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		UBX6_YEAST (159-293): 2.32e-32: 125: 22.79
+	Hs
		116676 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBXN8_HUMAN (75-294): 6.32e-35: 128: 15.32