HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	17353931, 33961781, 35271311, 15831487
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 392
+	Hs
		906912 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		907142 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		798748 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		792951 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		906981 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		792936 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		907118 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Sc
		744630 PRS4_YEAST (122-431): 4.87e-102: 312: 50.65		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Hs
		572915 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Sc
		636597 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Sc
		703696 PRS6A_YEAST (20-439): 2.06e-117: 351: 68.08		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		903081 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Mm
		907215 PRS8_MOUSE (65-437): 1.93e-126: 373: 44.39		PRP19_MOUSE (89-204): 4.15e-13: 72.4: 33.06
+	Sc
		636696 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		COPA_YEAST (3-376): 1.92e-44: 166: 10.58
+	Hs
		798631 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Sc
		771723 PRS4_YEAST (122-431): 4.87e-102: 312: 50.65		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		863386 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		COPA_HUMAN (4-376): 1.15e-43: 164: 12.85
+	Hs
		209413 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		PLRG1_HUMAN (269-390): 2.01e-20: 94.9: 14.84
+	Hs
		874768 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		875215 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		SNR40_HUMAN (308-388): 1.67e-09: 60.6: 11.63