HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25499913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 1298
+	Hs
		906916 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		907151 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		798753 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		1239603 AFG2A_HUMAN (182-435): 3.65e-68: 234: 35.32		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		572915 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		903081 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		798631 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		874768 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		792951 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		LIS1_HUMAN (123-346): 3.66e-35: 141: 11.45
+	Hs
		792936 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		LIS1_HUMAN (123-346): 3.66e-35: 141: 11.45
+	Hs
		907118 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58
+	Hs
		875215 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Sc
		744630 PRS4_YEAST (122-431): 4.87e-102: 312: 50.65		TAF5_YEAST (9-127): 1.2e-32: 139: 22.22
+	Sc
		636597 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		TAF5_YEAST (9-127): 1.2e-32: 139: 22.22
+	Sc
		636696 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		COPA_YEAST (12-143): 2.58e-16: 87.1: 16.43
+	Hs
		875370 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		WSB2_HUMAN (41-201): 1.66e-13: 75.9: 23.67