HitPredict - High confidence protein-protein interactions

Interactor 1: TCPA (P17987)
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
Gene: TCP1

Interactor 2: TCPZ (P40227)
T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20)
Gene: CCT6A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	35271311, 16085932
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~Cpn60_TCP1
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005832 - chaperonin-containing T-complex GO:0005874 - microtubule and 12 others more... GO:0006457 - protein folding GO:0016887 - ATP hydrolysis activity GO:0032212 - positive regulation of telomere maintenance via telomerase GO:0044183 - protein folding chaperone GO:0050821 - protein stabilization GO:0051082 - unfolded protein binding GO:0061077 - chaperone-mediated protein folding GO:0070062 - extracellular exosome GO:0140662 - ATP-dependent protein folding chaperone GO:1904851 - positive regulation of establishment of protein localization to telomere GO:1904871 - positive regulation of protein localization to Cajal body GO:1904874 - positive regulation of telomerase RNA localization to Cajal body
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1	556
Hs

1	531

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Last updated: 15 Jul 2024