HitPredict

Interactor 1: TCPA (P17987)
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
Gene: TCP1

Interactor 2: MKKS (Q9NPJ1)
Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)
Gene: MKKS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	20080638, 22500027
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~Cpn60_TCP1
Common GO terms	GO:0005524 - ATP binding GO:0005813 - centrosome GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 556 Hs			1 570
+	Hs
		573440 TCPA_HUMAN (1-556): 0: 630: 100.00		TCPH_HUMAN (9-531): 2.65e-167: 488: 16.21
+	Bt
		1102088 TCPA_BOVIN (1-555): 0: 630: 97.30		TCPH_BOVIN (9-529): 1.43e-165: 483: 15.91
+	Bt
		1103884 TCPA_BOVIN (1-555): 0: 630: 97.30		TCPG_BOVIN (4-519): 2.83e-164: 480: 19.05
+	Hs
		573172 TCPA_HUMAN (1-556): 0: 630: 100.00		TCPG_HUMAN (4-519): 7.61e-164: 479: 19.05
+	Hs
		573170 TCPA_HUMAN (1-556): 0: 630: 100.00		TCPE_HUMAN (1-516): 2.95e-162: 475: 15.54
+	Bt
		94407 TCPA_BOVIN (1-555): 0: 630: 97.30		F1MWD3_BOVIN (1-516): 1.53e-160: 470: 15.54
+	Hs
		573179 TCPA_HUMAN (1-556): 0: 630: 100.00		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Hs
		826843 TCPG_HUMAN (5-550): 0: 593: 33.03		TCPH_HUMAN (9-531): 2.65e-167: 488: 16.21
+	Mm
		945916 TCPH_MOUSE (1-551): 0: 577: 35.18		TCPH_MOUSE (9-536): 6.93e-172: 499: 16.19
+	Bt
		1102679 TCPA_BOVIN (1-555): 0: 630: 97.30		TCPD_BOVIN (19-515): 1.09e-150: 445: 18.27
+	Hs
		821117 TCPG_HUMAN (5-550): 0: 593: 33.03		TCPE_HUMAN (1-516): 2.95e-162: 475: 15.54
+	Hs
		826901 TCPG_HUMAN (5-550): 0: 593: 33.03		MKKS_HUMAN (1-570): 9.88e-158: 464: 100.00
+	Hs
		826574 TCPG_HUMAN (5-550): 0: 593: 33.03		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Hs
		821381 TCPH_HUMAN (1-545): 0: 566: 34.84		TCPE_HUMAN (1-516): 2.95e-162: 475: 15.54
+	Dm
		520044 TCPA_DROME (1-555): 0: 579: 73.33		Q9VHL2_DROME (6-523): 2.06e-150: 445: 15.63
+	Dm
		520034 TCPA_DROME (1-555): 0: 579: 73.33		Q7KKI0_DROME (5-516): 2.73e-150: 444: 16.39
+	Hs
		843351 TCPH_HUMAN (1-545): 0: 566: 34.84		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Dm
		520027 TCPA_DROME (1-555): 0: 579: 73.33		TCPG_DROME (6-490): 1.46e-136: 409: 18.32
+	Dm
		520045 TCPA_DROME (1-555): 0: 579: 73.33		Q9VK69_DROME (13-479): 2.08e-107: 334: 18.39