HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32912968, 8940099
Identification Methods	proximity labelling technology, phosphatase assay
Interaction Type	physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 317
+	Hs
		573970 PTN1_HUMAN (1-435): 0: 539: 100.00		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		570563 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		CSKI1_HUMAN (175-314): 1.19e-21: 97.7: 19.29
+	Hs
		577019 PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		489900 PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94		NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35
+	Hs
		883516 PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18		RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31
+	Hs
		1069970 PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18		Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31
+	Hs
		640286 PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		796421 PTN9_HUMAN (20-279): 3.35e-52: 186: 39.21		ANKH1_HUMAN (4-107): 2.55e-18: 87.9: 6.73
+	Hs
		640287 PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43		ANR50_HUMAN (2-66): 2.02e-09: 60.6: 4.62
+	Hs
		1206093 PTN22_HUMAN (297-430): 8.46e-19: 91.2: 13.10		MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11