HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.80	0.648

Property	Details
Experiments	12237455
Identification Methods	unspecified method, peptide array, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 864
+	Hs
		573975 PTN1_HUMAN (1-435): 0: 539: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		616937 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (21-787): 1.09e-167: 510: 20.78
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Hs
		435529 PTN1_HUMAN (1-435): 0: 539: 100.00		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		411291 PTN1_HUMAN (1-435): 0: 539: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		573629 PTN1_HUMAN (1-435): 0: 539: 100.00		EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42
+	Hs
		537715 PTN1_HUMAN (1-435): 0: 539: 100.00		INSRR_HUMAN (391-827): 1.68e-110: 369: 34.69
+	Hs
		411290 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		445820 PTN1_HUMAN (1-435): 0: 539: 100.00		ROS1_HUMAN (510-813): 5.35e-80: 285: 45.93
+	Hs
		725305 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		TIE1_HUMAN (192-785): 6.77e-134: 429: 25.63
+	Hs
		411297 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		411369 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		573718 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		384228 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		573716 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Hs
		384278 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		384743 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		616906 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		TEC_HUMAN (504-777): 1.34e-56: 207: 41.52