HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: ROR2 (Q01974)
Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)
Gene: ROR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 943
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (5-756): 8.41e-178: 539: 24.13
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (18-803): 1.13e-169: 517: 18.90
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (254-846): 1.68e-140: 449: 21.89
+	Hs
		573716 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK3_HUMAN (259-755): 4.11e-127: 406: 28.91
+	Hs
		573718 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK2_HUMAN (465-753): 4.36e-111: 363: 44.29
+	Hs
		601500 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR2_HUMAN (18-804): 9.32e-172: 522: 19.65
+	Hs
		616913 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		TIE2_HUMAN (2-755): 9.16e-144: 458: 19.44
+	Hs
		972322 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		TIE2_HUMAN (2-755): 9.16e-144: 458: 19.44
+	Hs
		384228 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK1_HUMAN (478-748): 6.27e-66: 238: 43.91
+	Hs
		573721 PTN1_HUMAN (1-435): 0: 539: 100.00		DDR2_HUMAN (461-751): 3.3e-55: 208: 38.39
+	Hs
		411291 PTN1_HUMAN (1-435): 0: 539: 100.00		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		435529 PTN1_HUMAN (1-435): 0: 539: 100.00		IGF1R_HUMAN (467-747): 1.28e-51: 199: 37.68
+	Hs
		411290 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		384278 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		NTRK1_HUMAN (478-748): 6.27e-66: 238: 43.91
+	Hs
		384743 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		NTRK1_HUMAN (478-748): 6.27e-66: 238: 43.91
+	Hs
		384692 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		NTRK1_HUMAN (478-748): 6.27e-66: 238: 43.91
+	Hs
		411297 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		411369 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		411361 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		INSR_HUMAN (467-747): 2.53e-53: 204: 39.15
+	Hs
		435618 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		IGF1R_HUMAN (467-747): 1.28e-51: 199: 37.68