HitPredict

Interactor 1: PTPRA (P18052)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28)
Gene: PTPRA

Interactor 2: FYN (P39688)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
Gene: FYN

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25951993, 9535845
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0044877 - protein-containing complex binding GO:0050804 - modulation of chemical synaptic transmission GO:0098685 - Schaffer collateral - CA1 synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 829 Mm			1 537
+	Rn
		1144045 Q66HJ7_RAT (1-829): 0: 986: 92.55		FYN_RAT (1-537): 0: 632: 99.81
+	Hs
		411997 PTPRA_HUMAN (1-829): 0: 973: 89.50		FYN_HUMAN (1-537): 0: 634: 99.44
+	Mm
		403413 PTPRA_MOUSE (1-829): 0: 1004: 100.00		SRC_MOUSE (1-537): 0: 594: 68.52
+	Rn
		1146020 Q66HJ7_RAT (1-829): 0: 986: 92.55		SRC_RAT (1-537): 0: 594: 68.33
+	Hs
		522756 PTPRA_HUMAN (1-829): 0: 973: 89.50		SRC_HUMAN (1-537): 0: 592: 68.76
+	Rn
		976063 PTPRA_RAT (1-829): 0: 970: 91.59		SRC_RAT (1-537): 0: 594: 68.33
+	Hs
		412016 PTPRD_HUMAN (14-827): 0: 885: 37.97		FYN_HUMAN (1-537): 0: 634: 99.44
+	Mm
		56907 PTPRF_MOUSE (4-827): 0: 875: 37.71		FYN_MOUSE (1-537): 0: 633: 100.00
+	Hs
		411959 PTPRF_HUMAN (4-827): 0: 866: 38.43		FYN_HUMAN (1-537): 0: 634: 99.44
+	Hs
		412017 PTPRE_HUMAN (112-829): 0: 810: 61.79		FYN_HUMAN (1-537): 0: 634: 99.44
+	Hs
		411565 PTPRF_HUMAN (4-827): 0: 866: 38.43		LCK_HUMAN (74-535): 0: 547: 61.04
+	Rn
		94284 F1LXJ9_RAT (2-822): 0: 777: 26.95		FYN_RAT (1-537): 0: 632: 99.81
+	Hs
		433255 PTPRE_HUMAN (112-829): 0: 810: 61.79		YES_HUMAN (1-537): 0: 581: 72.16
+	Hs
		411609 PTPRM_HUMAN (2-822): 0: 808: 29.15		LCK_HUMAN (74-535): 0: 547: 61.04
+	Hs
		411728 PTPRK_HUMAN (3-821): 0: 794: 29.08		LCK_HUMAN (74-535): 0: 547: 61.04
+	Dm
		337644 LAR_DROME (58-827): 0: 827: 36.39		ABL_DROME (66-537): 2.71e-162: 503: 42.02
+	Hs
		788993 PTPRK_HUMAN (3-821): 0: 794: 29.08		TEC_HUMAN (3-529): 7.11e-159: 468: 34.39
+	Dm
		337643 PTP69_DROME (149-826): 0: 656: 31.46		ABL_DROME (66-537): 2.71e-162: 503: 42.02
+	Hs
		411695 PTPRJ_HUMAN (543-824): 2.25e-119: 393: 39.22		LCK_HUMAN (74-535): 0: 547: 61.04
+	Hs
		788988 PTPRJ_HUMAN (543-824): 2.25e-119: 393: 39.22		TEC_HUMAN (3-529): 7.11e-159: 468: 34.39