HitPredict

Interactor 1: PTPRA (P18052)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28)
Gene: PTPRA

Interactor 2: PTPRD (Q64487)
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
Gene: PTPRD

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	10777529, 12376545
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Y_phosphatase~Y_phosphatase
Common GO terms	GO:0004725 - protein tyrosine phosphatase activity GO:0016311 - dephosphorylation GO:0043235 - receptor complex GO:0050804 - modulation of chemical synaptic transmission GO:0098685 - Schaffer collateral - CA1 synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 829 Mm			1 1912
+	Hs
		616971 PTPRS_HUMAN (5-827): 0: 889: 36.84		PTPRD_HUMAN (1-1912): 0: 1657: 98.12
+	Hs
		616939 PTPRD_HUMAN (14-827): 0: 885: 37.97		PTPRD_HUMAN (1-1912): 0: 1657: 98.12
+	Mm
		56906 PTPRA_MOUSE (1-829): 0: 1004: 100.00		PTPRF_MOUSE (1-1912): 0: 1531: 67.22
+	Mm
		69645 PTPRA_MOUSE (1-829): 0: 1004: 100.00		PTPRS_MOUSE (9-1912): 0: 1512: 70.07
+	Hs
		1031977 PTPRS_HUMAN (5-827): 0: 889: 36.84		PTPRS_HUMAN (1-1912): 0: 1556: 71.49
+	Hs
		489957 PTPRS_HUMAN (5-827): 0: 889: 36.84		PTPRF_HUMAN (1-1912): 0: 1521: 67.22
+	Mm
		573997 PTPRA_MOUSE (1-829): 0: 1004: 100.00		PTPRA_MOUSE (1142-1912): 0: 783: 39.07
+	Mm
		574002 PTPRA_MOUSE (1-829): 0: 1004: 100.00		PTPRE_MOUSE (1227-1912): 0: 762: 42.16
+	Hs
		576980 PTPRA_HUMAN (1-829): 0: 973: 89.50		PTPRA_HUMAN (1126-1912): 0: 790: 39.77
+	Hs
		576983 PTPRA_HUMAN (1-829): 0: 973: 89.50		PTPRE_HUMAN (1243-1912): 0: 767: 42.42
+	Mm
		828098 PTPRD_MOUSE (14-827): 0: 890: 37.85		PTPRE_MOUSE (1227-1912): 0: 762: 42.16
+	Mm
		69646 PTPRS_MOUSE (5-827): 0: 887: 36.26		PTPRE_MOUSE (1227-1912): 0: 762: 42.16
+	Hs
		576984 PTPRA_HUMAN (1-829): 0: 973: 89.50		PTPRG_HUMAN (1146-1909): 0: 674: 32.30
+	Mm
		573998 PTPRA_MOUSE (1-829): 0: 1004: 100.00		PTPRM_MOUSE (96-554): 5.96e-18: 93.1: 16.18
+	Mm
		574010 PTPRA_MOUSE (1-829): 0: 1004: 100.00		S4R1M0_MOUSE (495-811): 4.58e-10: 66.9: 13.50
+	Hs
		616916 PTPRS_HUMAN (5-827): 0: 889: 36.84		PTPRB_HUMAN (261-1223): 2.63e-39: 163: 13.11
+	Mm
		69654 PTPRS_MOUSE (5-827): 0: 887: 36.26		S4R1M0_MOUSE (495-811): 4.58e-10: 66.9: 13.50